Drug interactions
Feverfew + Nabumetone
Severity: Moderate
Feverfew and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Feverfew inhibits platelet aggregation in laboratory studies, so combining it with an NSAID could add to bleeding tendency. Clinical reports are limited.
What this interaction means in plain words
Feverfew and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive antiplatelet effects from feverfew constituents (e.g., parthenolide) and NSAID cyclooxygenase inhibition.
What to do
Advise avoiding feverfew supplements during nabumetone therapy or monitor for bruising and gastrointestinal bleeding. Stop feverfew before elective surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Feverfew with Nabumetone?
MediHelp rates the interaction as moderate. Feverfew and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Feverfew inhibits platelet aggregation in laboratory studies, so combining it with an NSAID could add to bleeding tendency. Clinical reports are limited.
How serious is the interaction between Feverfew and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding feverfew supplements during nabumetone therapy or monitor for bruising and gastrointestinal bleeding. Stop feverfew before elective surgery.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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