Drug interactions
Feverfew + Piroxicam
Severity: Moderate
Feverfew and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Feverfew inhibits platelet aggregation in vitro and may add to the bleeding tendency of piroxicam. Clinical reports of significant bleeding are limited.
What this interaction means in plain words
Feverfew and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Feverfew constituents such as parthenolide inhibit platelet function, adding to NSAID antiplatelet effects.
What to do
Advise avoiding feverfew supplements during piroxicam therapy, or monitor for bruising and bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Feverfew with Piroxicam?
MediHelp rates the interaction as moderate. Feverfew and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Feverfew inhibits platelet aggregation in vitro and may add to the bleeding tendency of piroxicam. Clinical reports of significant bleeding are limited.
How serious is the interaction between Feverfew and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding feverfew supplements during piroxicam therapy, or monitor for bruising and bleeding.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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