Drug interactions
Fexinidazole + Flibanserin
Severity: Contraindicated
Fexinidazole and Flibanserin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and raise flibanserin concentrations. Higher flibanserin exposure increases risk of severe hypotension, syncope and CNS depression.
What this interaction means in plain words
Fexinidazole and Flibanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
CYP3A4 inhibition reduces flibanserin metabolism.
What to do
Avoid concurrent use; flibanserin is contraindicated with moderate or strong CYP3A4 inhibitors. Choose an alternative if possible.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Fexinidazole with Flibanserin?
MediHelp rates the interaction as contraindicated. Fexinidazole and Flibanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fexinidazole may inhibit CYP3A4 and raise flibanserin concentrations. Higher flibanserin exposure increases risk of severe hypotension, syncope and CNS depression.
How serious is the interaction between Fexinidazole and Flibanserin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; flibanserin is contraindicated with moderate or strong CYP3A4 inhibitors. Choose an alternative if possible.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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