Drug interactions
Fexinidazole + Fluvoxamine
Severity: Moderate
Fexinidazole and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP1A2 and so could raise fluvoxamine levels. Fexinidazole also prolongs the QT interval, and fluvoxamine has a small QT liability, so the pair may increase arrhythmia risk.
What this interaction means in plain words
Fexinidazole and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole may inhibit CYP1A2, and both drugs have additive QT-prolonging potential.
What to do
Check an ECG and electrolytes before and during treatment if the combination is necessary, and monitor for fluvoxamine adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fexinidazole with Fluvoxamine?
MediHelp rates the interaction as moderate. Fexinidazole and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP1A2 and so could raise fluvoxamine levels. Fexinidazole also prolongs the QT interval, and fluvoxamine has a small QT liability, so the pair may increase arrhythmia risk.
How serious is the interaction between Fexinidazole and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and electrolytes before and during treatment if the combination is necessary, and monitor for fluvoxamine adverse effects.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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