Drug interactions
Fexinidazole + Gemifloxacin
Severity: Major
Fexinidazole and Gemifloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval and gemifloxacin shares this effect. Together they may produce additive QTc prolongation with a risk of torsades de pointes.
What this interaction means in plain words
Fexinidazole and Gemifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive potassium channel blockade causing delayed repolarization.
What to do
Avoid coadministration and use a non-QT-prolonging antibiotic. If unavoidable, monitor ECG and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Fexinidazole with Gemifloxacin?
MediHelp rates the interaction as major. Fexinidazole and Gemifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole can prolong the QT interval and gemifloxacin shares this effect. Together they may produce additive QTc prolongation with a risk of torsades de pointes.
How serious is the interaction between Fexinidazole and Gemifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and use a non-QT-prolonging antibiotic. If unavoidable, monitor ECG and correct electrolytes.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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