Drug interactions
Fexinidazole + Hydroxyzine
Severity: Major
Fexinidazole and Hydroxyzine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval and its labeling advises against combining it with other QT-prolonging drugs. Hydroxyzine increases the risk of torsades de pointes.
What this interaction means in plain words
Fexinidazole and Hydroxyzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QTc prolongation via cardiac potassium channel blockade.
What to do
Avoid hydroxyzine during fexinidazole therapy. If unavoidable, monitor ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Fexinidazole with Hydroxyzine?
MediHelp rates the interaction as major. Fexinidazole and Hydroxyzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole can prolong the QT interval and its labeling advises against combining it with other QT-prolonging drugs. Hydroxyzine increases the risk of torsades de pointes.
How serious is the interaction between Fexinidazole and Hydroxyzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid hydroxyzine during fexinidazole therapy. If unavoidable, monitor ECG and correct potassium and magnesium.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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