Drug interactions
Fexinidazole + Itraconazole
Severity: Major
Fexinidazole and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and the combination raises the risk of serious arrhythmia. Fexinidazole is also affected by CYP interactions that may alter exposure to its active metabolites and itraconazole levels.
What this interaction means in plain words
Fexinidazole and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, together with CYP-mediated effects on fexinidazole and itraconazole exposure.
What to do
Avoid the combination and use an antifungal without QT effect. If it cannot be avoided, monitor ECG and electrolytes and watch for reduced fexinidazole efficacy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Fexinidazole with Itraconazole?
MediHelp rates the interaction as major. Fexinidazole and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and the combination raises the risk of serious arrhythmia. Fexinidazole is also affected by CYP interactions that may alter exposure to its active metabolites and itraconazole levels.
How serious is the interaction between Fexinidazole and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antifungal without QT effect. If it cannot be avoided, monitor ECG and electrolytes and watch for reduced fexinidazole efficacy.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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