Drug interactions
Fexinidazole + Losartan
Severity: Moderate
Fexinidazole and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and could raise exposure to losartan's parent drug while reducing formation of its active metabolite, which is formed via CYP2C9 and CYP3A4. The net clinical effect is likely modest.
What this interaction means in plain words
Fexinidazole and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibition of CYP3A4 alters losartan metabolism.
What to do
Monitor blood pressure and for hypotension or reduced antihypertensive effect during the fexinidazole course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Fexinidazole with Losartan?
MediHelp rates the interaction as moderate. Fexinidazole and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and could raise exposure to losartan's parent drug while reducing formation of its active metabolite, which is formed via CYP2C9 and CYP3A4. The net clinical effect is likely modest.
How serious is the interaction between Fexinidazole and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for hypotension or reduced antihypertensive effect during the fexinidazole course.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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