Drug interactions
Fexinidazole + Lovastatin
Severity: Major
Fexinidazole and Lovastatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and may increase lovastatin exposure, raising the risk of myopathy and rhabdomyolysis. Lovastatin is highly dependent on CYP3A4 for clearance.
What this interaction means in plain words
Fexinidazole and Lovastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition by fexinidazole reduces lovastatin first-pass metabolism.
What to do
Hold lovastatin during the short fexinidazole course or switch to a statin not reliant on CYP3A4. Monitor for muscle symptoms if continued.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Fexinidazole with Lovastatin?
MediHelp rates the interaction as major. Fexinidazole and Lovastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole inhibits CYP3A4 and may increase lovastatin exposure, raising the risk of myopathy and rhabdomyolysis. Lovastatin is highly dependent on CYP3A4 for clearance.
How serious is the interaction between Fexinidazole and Lovastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold lovastatin during the short fexinidazole course or switch to a statin not reliant on CYP3A4. Monitor for muscle symptoms if continued.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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