Drug interactions
Fexinidazole + Lurasidone
Severity: Major
Fexinidazole and Lurasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and may raise lurasidone exposure. Lurasidone is contraindicated with strong CYP3A4 inhibitors, and increased levels raise the risk of adverse effects such as extrapyramidal symptoms and sedation.
What this interaction means in plain words
Fexinidazole and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lurasidone.
What to do
Avoid if possible. If fexinidazole must be used, monitor for lurasidone adverse effects and consider lowering the lurasidone dose during the short course.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Fexinidazole with Lurasidone?
MediHelp rates the interaction as major. Fexinidazole and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole inhibits CYP3A4 and may raise lurasidone exposure. Lurasidone is contraindicated with strong CYP3A4 inhibitors, and increased levels raise the risk of adverse effects such as extrapyramidal symptoms and sedation.
How serious is the interaction between Fexinidazole and Lurasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If fexinidazole must be used, monitor for lurasidone adverse effects and consider lowering the lurasidone dose during the short course.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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