Drug interactions
Fexinidazole + Norethisterone
Severity: Moderate
Fexinidazole and Norethisterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and may raise norethisterone concentrations. The clinical consequence is likely modest progestogenic adverse effects, and the interaction is largely predicted from the mechanism.
What this interaction means in plain words
Fexinidazole and Norethisterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, reducing the metabolic clearance of norethisterone.
What to do
Monitor for progestogen-related adverse effects such as bleeding changes, headache or nausea during the short fexinidazole course. Dose adjustment is usually unnecessary.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Frequently asked questions
Can I take Fexinidazole with Norethisterone?
MediHelp rates the interaction as moderate. Fexinidazole and Norethisterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole inhibits CYP3A4 and may raise norethisterone concentrations. The clinical consequence is likely modest progestogenic adverse effects, and the interaction is largely predicted from the mechanism.
How serious is the interaction between Fexinidazole and Norethisterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogen-related adverse effects such as bleeding changes, headache or nausea during the short fexinidazole course. Dose adjustment is usually unnecessary.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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