Drug interactions
Fexinidazole + Omeprazole
Severity: Minor
Fexinidazole and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and raise exposure to omeprazole, which is partly cleared by that enzyme. Clinical consequences are probably modest, as omeprazole has a wide therapeutic margin.
What this interaction means in plain words
Fexinidazole and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Fexinidazole inhibits CYP3A4, reducing omeprazole metabolism.
What to do
No routine adjustment is needed. Watch for omeprazole adverse effects during the short fexinidazole course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Fexinidazole with Omeprazole?
MediHelp rates the interaction as minor. Fexinidazole and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fexinidazole may inhibit CYP3A4 and raise exposure to omeprazole, which is partly cleared by that enzyme. Clinical consequences are probably modest, as omeprazole has a wide therapeutic margin.
How serious is the interaction between Fexinidazole and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for omeprazole adverse effects during the short fexinidazole course.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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