Drug interactions
Fexinidazole + Rimegepant
Severity: Moderate
Fexinidazole and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its metabolites may inhibit CYP3A4 and raise rimegepant concentrations. This could increase adverse effects.
What this interaction means in plain words
Fexinidazole and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 reduces rimegepant metabolism.
What to do
Avoid a second rimegepant dose within 48 hours of the first during fexinidazole treatment. Monitor tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Frequently asked questions
Can I take Fexinidazole with Rimegepant?
MediHelp rates the interaction as moderate. Fexinidazole and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its metabolites may inhibit CYP3A4 and raise rimegepant concentrations. This could increase adverse effects.
How serious is the interaction between Fexinidazole and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours of the first during fexinidazole treatment. Monitor tolerability.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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