Drug interactions
Fexinidazole + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Fexinidazole and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may induce CYP2B6 and inhibit CYP3A4, so the effect on velpatasvir and voxilaprevir exposure is unpredictable. Reduced levels could lead to loss of efficacy, while increased levels could cause adverse effects.
What this interaction means in plain words
Fexinidazole and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole induces CYP2B6 and inhibits CYP3A4, both of which contribute to velpatasvir metabolism, giving opposing effects.
What to do
Fexinidazole is given as a short course, so monitor for adverse effects and check HCV virologic response if possible. Consider deferring HCV therapy until after the course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Fexinidazole with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Fexinidazole and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may induce CYP2B6 and inhibit CYP3A4, so the effect on velpatasvir and voxilaprevir exposure is unpredictable. Reduced levels could lead to loss of efficacy, while increased levels could cause adverse effects.
How serious is the interaction between Fexinidazole and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Fexinidazole is given as a short course, so monitor for adverse effects and check HCV virologic response if possible. Consider deferring HCV therapy until after the course.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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