Drug interactions
Fexinidazole + Solifenacin
Severity: Major
Fexinidazole and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole prolongs the QT interval and inhibits CYP3A4, which raises solifenacin exposure. The combination increases the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Fexinidazole and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition that increases solifenacin concentrations.
What to do
Avoid solifenacin during fexinidazole treatment and use a non-QT-prolonging alternative. If it cannot be avoided, monitor ECG and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fexinidazole and Solifenacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Solifenacin
Frequently asked questions
Can I take Fexinidazole with Solifenacin?
MediHelp rates the interaction as major. Fexinidazole and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole prolongs the QT interval and inhibits CYP3A4, which raises solifenacin exposure. The combination increases the risk of serious ventricular arrhythmia.
How serious is the interaction between Fexinidazole and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid solifenacin during fexinidazole treatment and use a non-QT-prolonging alternative. If it cannot be avoided, monitor ECG and correct electrolytes.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
