Drug interactions
Fexinidazole + Tizanidine
Severity: Moderate
Fexinidazole and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its metabolites may inhibit CYP1A2, the main enzyme clearing tizanidine. Higher tizanidine exposure can cause marked hypotension, bradycardia and sedation.
What this interaction means in plain words
Fexinidazole and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP1A2-mediated tizanidine metabolism, raising tizanidine plasma concentrations.
What to do
Monitor blood pressure, heart rate and sedation during fexinidazole treatment, and reduce the tizanidine dose or use an alternative muscle relaxant if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Fexinidazole with Tizanidine?
MediHelp rates the interaction as moderate. Fexinidazole and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its metabolites may inhibit CYP1A2, the main enzyme clearing tizanidine. Higher tizanidine exposure can cause marked hypotension, bradycardia and sedation.
How serious is the interaction between Fexinidazole and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation during fexinidazole treatment, and reduce the tizanidine dose or use an alternative muscle relaxant if symptoms appear.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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