Drug interactions
Fexofenadine + Glecaprevir / pibrentasvir
Severity: Moderate
Fexofenadine and Glecaprevir / pibrentasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and OATP1B1/1B3, the transporters that govern fexofenadine absorption and hepatic uptake, so fexofenadine exposure may rise. Fexofenadine is well tolerated at higher exposure, so the effect is generally manageable.
What this interaction means in plain words
Fexofenadine and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-gp and OATP1B1/1B3 reduces fexofenadine efflux and hepatic uptake, increasing plasma levels.
What to do
Monitor for increased antihistamine adverse effects and reduce the fexofenadine dose if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
- Amifampridine + Fexofenadine Minor
Frequently asked questions
Can I take Fexofenadine with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as moderate. Fexofenadine and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-glycoprotein and OATP1B1/1B3, the transporters that govern fexofenadine absorption and hepatic uptake, so fexofenadine exposure may rise. Fexofenadine is well tolerated at higher exposure, so the effect is generally manageable.
How serious is the interaction between Fexofenadine and Glecaprevir / pibrentasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased antihistamine adverse effects and reduce the fexofenadine dose if they appear.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Grapefruit. The full list is on the Fexofenadine page.
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