Drug interactions
Danicopan + Fexofenadine
Severity: Moderate
Danicopan and Fexofenadine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and can increase exposure to fexofenadine, a sensitive P-gp substrate. Because fexofenadine has a wide therapeutic margin, the rise is usually tolerable but may increase adverse effects.
What this interaction means in plain words
Danicopan and Fexofenadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Fexofenadine belongs to Respiratory.
Why it happens
P-glycoprotein inhibition by danicopan reduces efflux of fexofenadine.
What to do
Monitor for increased fexofenadine adverse effects such as headache, dizziness or nausea. Consider reducing the fexofenadine dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fexofenadine
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
- Amifampridine + Fexofenadine Minor
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Fexofenadine?
MediHelp rates the interaction as moderate. Danicopan and Fexofenadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and can increase exposure to fexofenadine, a sensitive P-gp substrate. Because fexofenadine has a wide therapeutic margin, the rise is usually tolerable but may increase adverse effects.
How serious is the interaction between Danicopan and Fexofenadine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased fexofenadine adverse effects such as headache, dizziness or nausea. Consider reducing the fexofenadine dose if these occur.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Erdafitinib, Glecaprevir / pibrentasvir, Grapefruit. The full list is on the Fexofenadine page.
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