Drug interactions
Erdafitinib + Fexofenadine
Severity: Moderate
Erdafitinib and Fexofenadine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein, a key transporter in fexofenadine absorption and elimination, so fexofenadine exposure may increase. Because fexofenadine is well tolerated at higher exposure, the effect is usually modest.
What this interaction means in plain words
Erdafitinib and Fexofenadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Fexofenadine belongs to Respiratory.
Why it happens
P-glycoprotein inhibition by erdafitinib increases fexofenadine absorption and reduces its efflux.
What to do
Separate doses by at least 6 hours as suggested for P-gp substrates and monitor for adverse effects. No routine dose reduction is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
- Amifampridine + Fexofenadine Minor
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Fexofenadine?
MediHelp rates the interaction as moderate. Erdafitinib and Fexofenadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein, a key transporter in fexofenadine absorption and elimination, so fexofenadine exposure may increase. Because fexofenadine is well tolerated at higher exposure, the effect is usually modest.
How serious is the interaction between Erdafitinib and Fexofenadine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 6 hours as suggested for P-gp substrates and monitor for adverse effects. No routine dose reduction is needed.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Glecaprevir / pibrentasvir, Grapefruit. The full list is on the Fexofenadine page.
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