Drug interactions
Fexofenadine + Juice
Severity: Moderate
Fexofenadine and Juice: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit, orange and apple juice reduce the oral absorption of fexofenadine and can lower its plasma concentrations substantially, potentially weakening the antihistamine effect.
What this interaction means in plain words
Fexofenadine and Juice can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Juice constituents inhibit intestinal OATP1A2 and OATP2B1 uptake of fexofenadine, reducing its bioavailability.
What to do
Take fexofenadine with water and avoid taking it with fruit juice; separate by several hours if juice is consumed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Acrivastine + Fexofenadine Minor
- Amifampridine + Fexofenadine Minor
Frequently asked questions
Can I take Fexofenadine with Juice?
MediHelp rates the interaction as moderate. Fexofenadine and Juice can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Grapefruit, orange and apple juice reduce the oral absorption of fexofenadine and can lower its plasma concentrations substantially, potentially weakening the antihistamine effect.
How serious is the interaction between Fexofenadine and Juice?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take fexofenadine with water and avoid taking it with fruit juice; separate by several hours if juice is consumed.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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