Drug interactions
Fezolinetant + Peginterferon alfa 2a
Severity: Moderate
Fezolinetant and Peginterferon alfa 2a: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fezolinetant is metabolized mainly by CYP1A2, and CYP1A2 inhibitors raise its exposure and the risk of liver injury. Peginterferon alfa-2a is a known inhibitor of CYP1A2, which can increase fezolinetant levels, and interferon itself can cause liver abnormalities.
What this interaction means in plain words
Fezolinetant and Peginterferon alfa 2a can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fezolinetant belongs to Endocrine; Peginterferon alfa 2a belongs to Anti Virals.
Why it happens
Peginterferon alfa-2a reduces CYP1A2 activity, decreasing fezolinetant clearance.
What to do
Check liver function tests before starting and monitor them during combined therapy. Stop fezolinetant if signs of liver injury develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Peginterferon alfa 2a
Other interactions of Fezolinetant
- Cimetidine + Fezolinetant Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
Frequently asked questions
Can I take Fezolinetant with Peginterferon alfa 2a?
MediHelp rates the interaction as moderate. Fezolinetant and Peginterferon alfa 2a can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fezolinetant is metabolized mainly by CYP1A2, and CYP1A2 inhibitors raise its exposure and the risk of liver injury. Peginterferon alfa-2a is a known inhibitor of CYP1A2, which can increase fezolinetant levels, and interferon itself can cause liver abnormalities.
How serious is the interaction between Fezolinetant and Peginterferon alfa 2a?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver function tests before starting and monitor them during combined therapy. Stop fezolinetant if signs of liver injury develop.
What other medicines interact with Peginterferon alfa 2a?
MediHelp also lists interactions of Peginterferon alfa 2a with, for example, Clozapine, Deferiprone, Hydroxyurea. The full list is on the Peginterferon alfa 2a page.
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