Drug interactions
Fezolinetant + Propranolol
Severity: Moderate
Fezolinetant and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol is partly metabolized by CYP1A2 and may weakly inhibit it, which could raise fezolinetant concentrations. Increased exposure raises the risk of liver injury and other adverse effects of fezolinetant.
What this interaction means in plain words
Fezolinetant and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fezolinetant belongs to Endocrine; Propranolol belongs to Cardiovascular.
Why it happens
Possible CYP1A2 inhibition by propranolol reducing fezolinetant clearance; the effect is weak and not well characterized.
What to do
Monitor for adverse effects and liver tests per fezolinetant labeling; consider an alternative if hepatic abnormalities arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Fezolinetant
- Cimetidine + Fezolinetant Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
Frequently asked questions
Can I take Fezolinetant with Propranolol?
MediHelp rates the interaction as moderate. Fezolinetant and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol is partly metabolized by CYP1A2 and may weakly inhibit it, which could raise fezolinetant concentrations. Increased exposure raises the risk of liver injury and other adverse effects of fezolinetant.
How serious is the interaction between Fezolinetant and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and liver tests per fezolinetant labeling; consider an alternative if hepatic abnormalities arise.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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