Drug interactions
Fingolimod + Fluticasone-vilanterol
Severity: Moderate
Fingolimod and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod causes bradycardia and has been associated with QT prolongation and arrhythmias at treatment initiation. Vilanterol may add cardiac effects and hypokalemia.
What this interaction means in plain words
Fingolimod and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive effects on cardiac conduction and repolarization.
What to do
Monitor ECG and heart rate, particularly around fingolimod initiation, and correct electrolyte disturbances.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Fingolimod and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod causes bradycardia and has been associated with QT prolongation and arrhythmias at treatment initiation. Vilanterol may add cardiac effects and hypokalemia.
How serious is the interaction between Fingolimod and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate, particularly around fingolimod initiation, and correct electrolyte disturbances.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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