Drug interactions
Fingolimod + Fostemsavir
Severity: Moderate
Fingolimod and Fostemsavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir causes QT prolongation at supratherapeutic exposures, and fingolimod can slow heart rate and has QT concerns. Combined use may add to torsades risk when other risk factors exist.
What this interaction means in plain words
Fingolimod and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Fostemsavir belongs to Anti Virals.
Why it happens
Possible additive QT prolongation with fingolimod-induced bradycardia.
What to do
Obtain a baseline ECG and monitor it during fingolimod initiation. Avoid in patients with congenital long QT, and correct electrolyte disturbances.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fingolimod with Fostemsavir?
MediHelp rates the interaction as moderate. Fingolimod and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir causes QT prolongation at supratherapeutic exposures, and fingolimod can slow heart rate and has QT concerns. Combined use may add to torsades risk when other risk factors exist.
How serious is the interaction between Fingolimod and Fostemsavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during fingolimod initiation. Avoid in patients with congenital long QT, and correct electrolyte disturbances.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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