Drug interactions
Fingolimod + Lapatinib
Severity: Major
Fingolimod and Lapatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib can prolong the QT interval, and fingolimod causes bradycardia and may add QT effects. The combination increases the risk of torsades de pointes, especially with electrolyte abnormalities.
What this interaction means in plain words
Fingolimod and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Lapatinib belongs to Oncology.
Why it happens
Additive QT prolongation with fingolimod-related bradycardia.
What to do
Obtain baseline ECG and electrolytes, correct hypokalemia and hypomagnesemia, and monitor ECG; consider alternatives in patients with other QT risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Fingolimod with Lapatinib?
MediHelp rates the interaction as major. Fingolimod and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lapatinib can prolong the QT interval, and fingolimod causes bradycardia and may add QT effects. The combination increases the risk of torsades de pointes, especially with electrolyte abnormalities.
How serious is the interaction between Fingolimod and Lapatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG and electrolytes, correct hypokalemia and hypomagnesemia, and monitor ECG; consider alternatives in patients with other QT risk factors.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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