Drug interactions
Fingolimod + Mitoxantrone
Severity: Major
Fingolimod and Mitoxantrone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitoxantrone is myelosuppressive and immunosuppressive, and is also used in multiple sclerosis. With fingolimod, immunosuppression and infection risk may be increased, and prior mitoxantrone exposure has persistent effects.
What this interaction means in plain words
Fingolimod and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Mitoxantrone belongs to Central Nervous System.
Why it happens
Additive immunosuppression from mitoxantrone marrow suppression and fingolimod lymphocyte sequestration.
What to do
Avoid concurrent use; when switching from mitoxantrone, check blood counts and allow recovery before starting fingolimod. Monitor for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Mitoxantrone
Frequently asked questions
Can I take Fingolimod with Mitoxantrone?
MediHelp rates the interaction as major. Fingolimod and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitoxantrone is myelosuppressive and immunosuppressive, and is also used in multiple sclerosis. With fingolimod, immunosuppression and infection risk may be increased, and prior mitoxantrone exposure has persistent effects.
How serious is the interaction between Fingolimod and Mitoxantrone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; when switching from mitoxantrone, check blood counts and allow recovery before starting fingolimod. Monitor for infection.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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