Drug interactions
Fingolimod + Primaquine
Severity: Moderate
Fingolimod and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod causes bradycardia and can affect cardiac conduction, and primaquine may prolong the QT interval. Combining them could increase the risk of arrhythmia, particularly after the first fingolimod dose.
What this interaction means in plain words
Fingolimod and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Primaquine belongs to Anti Parasitic.
Why it happens
Additive effects on cardiac repolarization and conduction, with fingolimod-induced bradycardia increasing the risk of QT-related arrhythmia.
What to do
Perform an ECG before starting and monitor heart rate and rhythm, especially during fingolimod initiation. Avoid starting fingolimod during primaquine therapy in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Primaquine?
MediHelp rates the interaction as moderate. Fingolimod and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod causes bradycardia and can affect cardiac conduction, and primaquine may prolong the QT interval. Combining them could increase the risk of arrhythmia, particularly after the first fingolimod dose.
How serious is the interaction between Fingolimod and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform an ECG before starting and monitor heart rate and rhythm, especially during fingolimod initiation. Avoid starting fingolimod during primaquine therapy in patients with QT risk factors.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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