Drug interactions
Fingolimod + Propafenone
Severity: Major
Fingolimod and Propafenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod causes bradycardia and AV conduction delay after the first dose and can prolong the QT interval. Propafenone also slows conduction, so combined use may increase the risk of marked bradycardia, heart block and arrhythmia.
What this interaction means in plain words
Fingolimod and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Propafenone belongs to Cardiovascular.
Why it happens
Additive effects on heart rate, AV conduction and QT interval.
What to do
Avoid starting fingolimod in patients on propafenone unless benefits outweigh risks, and seek cardiology advice. If used, give the first dose with extended ECG and heart rate monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Propafenone?
MediHelp rates the interaction as major. Fingolimod and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fingolimod causes bradycardia and AV conduction delay after the first dose and can prolong the QT interval. Propafenone also slows conduction, so combined use may increase the risk of marked bradycardia, heart block and arrhythmia.
How serious is the interaction between Fingolimod and Propafenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting fingolimod in patients on propafenone unless benefits outweigh risks, and seek cardiology advice. If used, give the first dose with extended ECG and heart rate monitoring.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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