Drug interactions
Fingolimod + Sertraline
Severity: Moderate
Fingolimod and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod causes bradycardia and can prolong the QT interval, and sertraline has a small QT-prolonging effect. Together they may raise the risk of arrhythmia, especially at treatment initiation. Patients with cardiac disease or electrolyte disturbances are most at risk.
What this interaction means in plain words
Fingolimod and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization together with fingolimod-induced bradycardia.
What to do
Obtain a baseline ECG and correct potassium and magnesium before starting fingolimod, and observe heart rate after the first dose. Consider repeat ECG monitoring in patients with additional QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Sertraline?
MediHelp rates the interaction as moderate. Fingolimod and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod causes bradycardia and can prolong the QT interval, and sertraline has a small QT-prolonging effect. Together they may raise the risk of arrhythmia, especially at treatment initiation. Patients with cardiac disease or electrolyte disturbances are most at risk.
How serious is the interaction between Fingolimod and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before starting fingolimod, and observe heart rate after the first dose. Consider repeat ECG monitoring in patients with additional QT risk factors.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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