Drug interactions
Fingolimod + Umeclidinium-vilanterol
Severity: Moderate
Fingolimod and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod causes bradycardia and atrioventricular conduction delay after the first dose and can be associated with QT effects. Vilanterol, a beta-2 agonist, can cause tachycardia and arrhythmia, and fingolimod may blunt the bronchodilator response to beta-agonists. The combination calls for cardiac attention, particularly around fingolimod initiation.
What this interaction means in plain words
Fingolimod and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Opposing and additive cardiac effects: fingolimod S1P-mediated bradycardia and conduction slowing versus beta-2 agonist cardiac stimulation and QT effects.
What to do
Monitor heart rate, blood pressure and ECG at fingolimod initiation and in patients with cardiac risk factors. Assess respiratory control if beta-agonist response appears reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Fingolimod and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod causes bradycardia and atrioventricular conduction delay after the first dose and can be associated with QT effects. Vilanterol, a beta-2 agonist, can cause tachycardia and arrhythmia, and fingolimod may blunt the bronchodilator response to beta-agonists. The combination calls for cardiac attention, particularly around fingolimod initiation.
How serious is the interaction between Fingolimod and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG at fingolimod initiation and in patients with cardiac risk factors. Assess respiratory control if beta-agonist response appears reduced.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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