Drug interactions
Fingolimod + Ustekinumab
Severity: Moderate
Fingolimod and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using these two immunomodulators together may increase susceptibility to infection. Fingolimod's effect on lymphocyte counts lasts for weeks after discontinuation, so overlap persists during a switch.
What this interaction means in plain words
Fingolimod and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from IL-12/23 inhibition and S1P receptor modulation with lymphocyte sequestration.
What to do
Avoid unnecessary combination and monitor for infections when transitioning. Review lymphocyte counts and the washout timing of fingolimod.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Ustekinumab?
MediHelp rates the interaction as moderate. Fingolimod and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using these two immunomodulators together may increase susceptibility to infection. Fingolimod's effect on lymphocyte counts lasts for weeks after discontinuation, so overlap persists during a switch.
How serious is the interaction between Fingolimod and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary combination and monitor for infections when transitioning. Review lymphocyte counts and the washout timing of fingolimod.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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