Drug interactions
Fingolimod + Vardenafil
Severity: Moderate
Fingolimod and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod can cause bradycardia and has been associated with QT prolongation, and vardenafil may add a small QT effect. Together they may increase the risk of arrhythmia in susceptible patients.
What this interaction means in plain words
Fingolimod and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Vardenafil belongs to Genitourinary.
Why it happens
Additive effects on cardiac conduction and repolarization.
What to do
Monitor heart rate and consider an ECG in patients with cardiac disease or other QT-prolonging drugs. Avoid the combination in patients with known long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Vardenafil?
MediHelp rates the interaction as moderate. Fingolimod and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod can cause bradycardia and has been associated with QT prolongation, and vardenafil may add a small QT effect. Together they may increase the risk of arrhythmia in susceptible patients.
How serious is the interaction between Fingolimod and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and consider an ECG in patients with cardiac disease or other QT-prolonging drugs. Avoid the combination in patients with known long QT syndrome.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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