Drug interactions
Fingolimod + Voclosporin
Severity: Moderate
Fingolimod and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is an immunosuppressant that can prolong the QT interval at higher exposures, and fingolimod adds immunosuppression and bradycardia. Together there is a greater risk of infection and, in susceptible patients, arrhythmia.
What this interaction means in plain words
Fingolimod and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Voclosporin belongs to Miscellaneous.
Why it happens
Additive immunosuppression and possible additive QT prolongation with bradycardia.
What to do
Monitor for infection and check ECG and electrolytes in patients with cardiac risk factors. Monitor lymphocyte counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Fingolimod with Voclosporin?
MediHelp rates the interaction as moderate. Fingolimod and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is an immunosuppressant that can prolong the QT interval at higher exposures, and fingolimod adds immunosuppression and bradycardia. Together there is a greater risk of infection and, in susceptible patients, arrhythmia.
How serious is the interaction between Fingolimod and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and check ECG and electrolytes in patients with cardiac risk factors. Monitor lymphocyte counts.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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