Drug interactions
Fingolimod + Ziprasidone
Severity: Major
Fingolimod and Ziprasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod slows heart rate and can prolong the QT interval after the first dose, and ziprasidone adds QT prolongation. This combination increases the risk of bradycardia-related torsades de pointes.
What this interaction means in plain words
Fingolimod and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive QTc prolongation combined with fingolimod-induced bradycardia.
What to do
Avoid concurrent use where possible; seek cardiology advice before starting fingolimod in patients on ziprasidone. If combined, use extended ECG monitoring at fingolimod initiation and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Ziprasidone?
MediHelp rates the interaction as major. Fingolimod and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fingolimod slows heart rate and can prolong the QT interval after the first dose, and ziprasidone adds QT prolongation. This combination increases the risk of bradycardia-related torsades de pointes.
How serious is the interaction between Fingolimod and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; seek cardiology advice before starting fingolimod in patients on ziprasidone. If combined, use extended ECG monitoring at fingolimod initiation and correct electrolytes.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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