Drug interactions
Fish oil + Prasugrel
Severity: Moderate
Fish oil and Prasugrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omega-3 fatty acids have mild antiplatelet effects, and prasugrel is a potent P2Y12 inhibitor associated with significant bleeding. Together bleeding risk may be somewhat increased.
What this interaction means in plain words
Fish oil and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fish oil belongs to Gastrointestinal Tract; Prasugrel belongs to Cardiovascular.
Why it happens
Additive platelet inhibition from irreversible P2Y12 blockade and omega-3 effects on platelet function.
What to do
Monitor for bleeding and bruising; avoid high-dose fish oil unless there is a clear indication.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fish oil
- Antithrombin alfa + Fish oil Moderate
- Antithrombin iii + Fish oil Moderate
- Aspirin / citric acid / sodium bicarbonate + Fish oil Moderate
- Aspirin + Fish oil Moderate
- Betrixaban + Fish oil Moderate
- Bivalirudin + Fish oil Moderate
Other interactions of Prasugrel
Frequently asked questions
Can I take Fish oil with Prasugrel?
MediHelp rates the interaction as moderate. Fish oil and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omega-3 fatty acids have mild antiplatelet effects, and prasugrel is a potent P2Y12 inhibitor associated with significant bleeding. Together bleeding risk may be somewhat increased.
How serious is the interaction between Fish oil and Prasugrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and bruising; avoid high-dose fish oil unless there is a clear indication.
What other medicines interact with Fish oil?
MediHelp also lists interactions of Fish oil with, for example, Antithrombin alfa, Antithrombin iii, Aspirin / citric acid / sodium bicarbonate. The full list is on the Fish oil page.
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