Drug interactions
Fish oil triglycerides + Mefenamic acid
Severity: Moderate
Fish oil triglycerides and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omega-3 fatty acids can modestly prolong bleeding time, and NSAIDs impair platelet function and damage gastric mucosa. Together they may increase the chance of bleeding, although serious events are uncommon.
What this interaction means in plain words
Fish oil triglycerides and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects: omega-3 fatty acids reduce platelet aggregation while NSAIDs inhibit thromboxane synthesis.
What to do
Monitor for signs of bleeding and consider periodic assessment of bleeding parameters in high-risk patients. Use the shortest NSAID course possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Fish oil triglycerides with Mefenamic acid?
MediHelp rates the interaction as moderate. Fish oil triglycerides and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omega-3 fatty acids can modestly prolong bleeding time, and NSAIDs impair platelet function and damage gastric mucosa. Together they may increase the chance of bleeding, although serious events are uncommon.
How serious is the interaction between Fish oil triglycerides and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and consider periodic assessment of bleeding parameters in high-risk patients. Use the shortest NSAID course possible.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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