Drug interactions
Fish oil triglycerides + Rivaroxaban
Severity: Minor
Fish oil triglycerides and Rivaroxaban: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose omega-3 fatty acids have mild antiplatelet effects and may prolong bleeding time. Together with rivaroxaban, they may modestly increase bleeding risk, though clinically significant events are uncommon.
What this interaction means in plain words
Fish oil triglycerides and Rivaroxaban have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic effect through omega-3 inhibition of platelet aggregation.
What to do
No dose change is generally needed, but ask patients to report bruising or bleeding. Monitor for bleeding when high doses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Fish oil triglycerides with Rivaroxaban?
MediHelp rates the interaction as minor. Fish oil triglycerides and Rivaroxaban have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. High-dose omega-3 fatty acids have mild antiplatelet effects and may prolong bleeding time. Together with rivaroxaban, they may modestly increase bleeding risk, though clinically significant events are uncommon.
How serious is the interaction between Fish oil triglycerides and Rivaroxaban?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed, but ask patients to report bruising or bleeding. Monitor for bleeding when high doses are used.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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