Drug interactions
Flavoxate + Imipramine
Severity: Moderate
Flavoxate and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine is a tricyclic antidepressant with marked anticholinergic effects. With flavoxate it may cause additive dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion.
What this interaction means in plain words
Flavoxate and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flavoxate belongs to Genitourinary; Imipramine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for urinary retention, constipation and cognitive effects. Consider a less anticholinergic antidepressant if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flavoxate
- Clozapine + Flavoxate Major
- Abobotulinumtoxina + Flavoxate Moderate
- Aclidinium + Flavoxate Moderate
- Amantadine + Flavoxate Moderate
- Amitriptyline + Flavoxate Moderate
- Amoxapine + Flavoxate Moderate
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Flavoxate with Imipramine?
MediHelp rates the interaction as moderate. Flavoxate and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine is a tricyclic antidepressant with marked anticholinergic effects. With flavoxate it may cause additive dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion.
How serious is the interaction between Flavoxate and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and cognitive effects. Consider a less anticholinergic antidepressant if symptoms develop.
What other medicines interact with Flavoxate?
MediHelp also lists interactions of Flavoxate with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Flavoxate page.
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