Drug interactions
Flecainide + Ofloxacin
Severity: Major
Flecainide and Ofloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flecainide slows cardiac conduction and can be proarrhythmic, and ofloxacin may prolong repolarization. Together they may increase the risk of serious ventricular arrhythmias, especially in structural heart disease.
What this interaction means in plain words
Flecainide and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flecainide belongs to Cardiovascular; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive effects on cardiac conduction and repolarization through ion channel blockade.
What to do
Use a non-quinolone antibiotic when possible. If the combination is needed, monitor the ECG for QRS and QT changes and keep potassium and magnesium within normal ranges.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Frequently asked questions
Can I take Flecainide with Ofloxacin?
MediHelp rates the interaction as major. Flecainide and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Flecainide slows cardiac conduction and can be proarrhythmic, and ofloxacin may prolong repolarization. Together they may increase the risk of serious ventricular arrhythmias, especially in structural heart disease.
How serious is the interaction between Flecainide and Ofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-quinolone antibiotic when possible. If the combination is needed, monitor the ECG for QRS and QT changes and keep potassium and magnesium within normal ranges.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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