Drug interactions
Flecainide + Propranolol
Severity: Moderate
Flecainide and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress myocardial contractility and conduction, so combined use can cause bradycardia, AV block and worsening heart failure. Propranolol may also raise flecainide exposure modestly, and flecainide may raise propranolol exposure.
What this interaction means in plain words
Flecainide and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flecainide belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive negative inotropic and dromotropic effects, with possible mutual reduction in hepatic clearance.
What to do
Monitor heart rate, ECG intervals (PR and QRS) and signs of heart failure when starting or adjusting either drug. Reduce doses if bradycardia, conduction delay or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Frequently asked questions
Can I take Flecainide with Propranolol?
MediHelp rates the interaction as moderate. Flecainide and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress myocardial contractility and conduction, so combined use can cause bradycardia, AV block and worsening heart failure. Propranolol may also raise flecainide exposure modestly, and flecainide may raise propranolol exposure.
How serious is the interaction between Flecainide and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG intervals (PR and QRS) and signs of heart failure when starting or adjusting either drug. Reduce doses if bradycardia, conduction delay or hypotension develops.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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