Drug interactions
Fleroxacin + Insulin glargine
Severity: Moderate
Fleroxacin and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can disturb glucose homeostasis, causing either hypoglycemia or hyperglycemia, and the risk is greatest in patients receiving insulin or other antidiabetic drugs. Severe hypoglycemia, including coma, has been reported with this class.
What this interaction means in plain words
Fleroxacin and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluoroquinolones may stimulate pancreatic beta-cell insulin release by blocking ATP-sensitive potassium channels, adding to the effect of exogenous insulin.
What to do
Monitor blood glucose closely during and shortly after the quinolone course, and adjust the insulin glargine dose as needed. Educate the patient about the symptoms of hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Frequently asked questions
Can I take Fleroxacin with Insulin glargine?
MediHelp rates the interaction as moderate. Fleroxacin and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can disturb glucose homeostasis, causing either hypoglycemia or hyperglycemia, and the risk is greatest in patients receiving insulin or other antidiabetic drugs. Severe hypoglycemia, including coma, has been reported with this class.
How serious is the interaction between Fleroxacin and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and shortly after the quinolone course, and adjust the insulin glargine dose as needed. Educate the patient about the symptoms of hypoglycemia.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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