Drug interactions
Fleroxacin + Magnesium hydroxide
Severity: Moderate
Fleroxacin and Magnesium hydroxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium in antacids forms chelate complexes with fluoroquinolones in the gut. This reduces fleroxacin absorption and can lead to subtherapeutic antibiotic concentrations and treatment failure.
What this interaction means in plain words
Fleroxacin and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of fleroxacin by divalent magnesium cations in the gastrointestinal tract reduces its absorption.
What to do
Give fleroxacin at least 2 hours before or after magnesium hydroxide. Monitor for therapeutic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fleroxacin and Magnesium hydroxide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Magnesium hydroxide
Frequently asked questions
Can I take Fleroxacin with Magnesium hydroxide?
MediHelp rates the interaction as moderate. Fleroxacin and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium in antacids forms chelate complexes with fluoroquinolones in the gut. This reduces fleroxacin absorption and can lead to subtherapeutic antibiotic concentrations and treatment failure.
How serious is the interaction between Fleroxacin and Magnesium hydroxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give fleroxacin at least 2 hours before or after magnesium hydroxide. Monitor for therapeutic response.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
