Drug interactions
Fleroxacin + Midazolam
Severity: Minor
Fleroxacin and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones such as fleroxacin may slightly reduce the metabolism of midazolam, which can raise its levels. The effect is probably small and seldom clinically important.
What this interaction means in plain words
Fleroxacin and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Fleroxacin may weakly inhibit CYP-mediated metabolism of midazolam.
What to do
Monitor for prolonged sedation, especially with oral midazolam or repeated dosing. No empirical dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Fleroxacin with Midazolam?
MediHelp rates the interaction as minor. Fleroxacin and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoroquinolones such as fleroxacin may slightly reduce the metabolism of midazolam, which can raise its levels. The effect is probably small and seldom clinically important.
How serious is the interaction between Fleroxacin and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for prolonged sedation, especially with oral midazolam or repeated dosing. No empirical dose change is usually needed.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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