Drug interactions
Flibanserin + Fosamprenavir
Severity: Contraindicated
Flibanserin and Fosamprenavir: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir is converted to amprenavir, a CYP3A4 inhibitor, which can increase flibanserin levels. Severe hypotension, syncope and sedation may occur.
What this interaction means in plain words
Flibanserin and Fosamprenavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Inhibition of CYP3A4 reduces flibanserin metabolism.
What to do
Do not combine; avoid flibanserin in patients on fosamprenavir, especially ritonavir-boosted regimens.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Fosamprenavir?
MediHelp rates the interaction as contraindicated. Flibanserin and Fosamprenavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fosamprenavir is converted to amprenavir, a CYP3A4 inhibitor, which can increase flibanserin levels. Severe hypotension, syncope and sedation may occur.
How serious is the interaction between Flibanserin and Fosamprenavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; avoid flibanserin in patients on fosamprenavir, especially ritonavir-boosted regimens.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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