Drug interactions
Flibanserin + Glecaprevir / pibrentasvir
Severity: Minor
Flibanserin and Glecaprevir / pibrentasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin inhibits P-glycoprotein and may increase exposure to P-gp substrates such as glecaprevir and pibrentasvir. The magnitude is likely modest and the clinical significance is uncertain.
What this interaction means in plain words
Flibanserin and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Flibanserin inhibits intestinal P-glycoprotein efflux, potentially increasing absorption of the antivirals.
What to do
No routine adjustment is needed. Monitor for antiviral adverse effects such as headache, fatigue and liver enzyme changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as minor. Flibanserin and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Flibanserin inhibits P-glycoprotein and may increase exposure to P-gp substrates such as glecaprevir and pibrentasvir. The magnitude is likely modest and the clinical significance is uncertain.
How serious is the interaction between Flibanserin and Glecaprevir / pibrentasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for antiviral adverse effects such as headache, fatigue and liver enzyme changes.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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