Drug interactions
Flibanserin + Grapefruit
Severity: Contraindicated
Flibanserin and Grapefruit: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit products inhibit intestinal CYP3A4 and can raise flibanserin levels. This increases the risk of severe hypotension, syncope and sedation.
What this interaction means in plain words
Flibanserin and Grapefruit are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Grapefruit furanocoumarins inhibit intestinal CYP3A4, reducing first-pass metabolism of flibanserin.
What to do
Advise patients to avoid grapefruit and grapefruit juice while taking flibanserin.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Grapefruit?
MediHelp rates the interaction as contraindicated. Flibanserin and Grapefruit are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Grapefruit products inhibit intestinal CYP3A4 and can raise flibanserin levels. This increases the risk of severe hypotension, syncope and sedation.
How serious is the interaction between Flibanserin and Grapefruit?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid grapefruit and grapefruit juice while taking flibanserin.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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