Drug interactions
Flibanserin + Lansoprazole
Severity: Moderate
Flibanserin and Lansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin exposure rises with CYP3A4 inhibitors, and the labeling warns about combining several weak inhibitors. Lansoprazole is a weak inhibitor, so by itself the effect is limited, but combined with other weak inhibitors it may contribute to hypotension, syncope and sedation.
What this interaction means in plain words
Flibanserin and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Weak CYP3A4 inhibition by lansoprazole may increase flibanserin exposure.
What to do
Avoid adding further CYP3A4 inhibitors, and counsel on dizziness, hypotension and sedation. Avoid alcohol around dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Lansoprazole?
MediHelp rates the interaction as moderate. Flibanserin and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin exposure rises with CYP3A4 inhibitors, and the labeling warns about combining several weak inhibitors. Lansoprazole is a weak inhibitor, so by itself the effect is limited, but combined with other weak inhibitors it may contribute to hypotension, syncope and sedation.
How serious is the interaction between Flibanserin and Lansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid adding further CYP3A4 inhibitors, and counsel on dizziness, hypotension and sedation. Avoid alcohol around dosing.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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