Drug interactions
Flibanserin + Levorphanol
Severity: Major
Flibanserin and Levorphanol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids and flibanserin both cause sedation, dizziness and syncope. Combined use may deepen CNS depression and increase the risk of hypotension and falls, and with opioids potentially respiratory depression.
What this interaction means in plain words
Flibanserin and Levorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic CNS depression and hypotensive effects.
What to do
Avoid the combination where possible; if opioid therapy is required, use the lowest opioid dose and monitor for sedation, respiratory depression and hypotension. Advise against alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Levorphanol?
MediHelp rates the interaction as major. Flibanserin and Levorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids and flibanserin both cause sedation, dizziness and syncope. Combined use may deepen CNS depression and increase the risk of hypotension and falls, and with opioids potentially respiratory depression.
How serious is the interaction between Flibanserin and Levorphanol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if opioid therapy is required, use the lowest opioid dose and monitor for sedation, respiratory depression and hypotension. Advise against alcohol and driving.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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