Drug interactions
Flibanserin + Mestranol
Severity: Moderate
Flibanserin and Mestranol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mestranol is metabolized to ethinylestradiol and acts as a weak CYP3A4 inhibitor like other estrogen components of oral contraceptives. Flibanserin exposure may rise modestly, increasing dizziness, sedation and hypotension.
What this interaction means in plain words
Flibanserin and Mestranol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mestranol, via ethinylestradiol, weakly inhibits CYP3A4 and reduces flibanserin clearance.
What to do
Counsel on dizziness, somnolence and syncope, especially if other CYP3A4 inhibitors are used. Monitor tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Flibanserin and Mestranol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Mestranol?
MediHelp rates the interaction as moderate. Flibanserin and Mestranol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mestranol is metabolized to ethinylestradiol and acts as a weak CYP3A4 inhibitor like other estrogen components of oral contraceptives. Flibanserin exposure may rise modestly, increasing dizziness, sedation and hypotension.
How serious is the interaction between Flibanserin and Mestranol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on dizziness, somnolence and syncope, especially if other CYP3A4 inhibitors are used. Monitor tolerability.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
