Drug interactions
Flibanserin + Midazolam intranasal
Severity: Major
Flibanserin and Midazolam intranasal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a benzodiazepine that causes sedation and respiratory depression, and flibanserin adds CNS depression, dizziness and hypotension or syncope. The combination may cause prolonged or excessive sedation and hypoventilation.
What this interaction means in plain words
Flibanserin and Midazolam intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic CNS depression; flibanserin is also a CYP3A4 substrate with weak inhibitory effects.
What to do
Monitor respiratory rate, oxygen saturation and level of consciousness after midazolam dosing, with resuscitation equipment available. Avoid giving the dose within hours of flibanserin in patients at risk, and avoid alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Midazolam intranasal?
MediHelp rates the interaction as major. Flibanserin and Midazolam intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Midazolam is a benzodiazepine that causes sedation and respiratory depression, and flibanserin adds CNS depression, dizziness and hypotension or syncope. The combination may cause prolonged or excessive sedation and hypoventilation.
How serious is the interaction between Flibanserin and Midazolam intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate, oxygen saturation and level of consciousness after midazolam dosing, with resuscitation equipment available. Avoid giving the dose within hours of flibanserin in patients at risk, and avoid alcohol.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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